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ISSN: 2414-3146

November 2020 issue

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Cover illustration: The solid-state structure of 4-hy­droxy-N,N-di-n-propyl­tryptammonium (4-HO-DPT) chloride is the first of a psilocin analogue as its hydro­chloride salt. When used as pharmaceuticals, amines are often converted to their hydro­chloride salts to increase their solubility in water, and thus improving drug delivery. 4-HO-DPT is a structural analogue of psilocin and produces similar (though not identical) psychedelic effects in human subjects. See: Sammeta, Rasapalli, Chadeayne, Golen & Manke [IUCrData (2020). 5, x201546].

metal-organic compounds


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The title compound, [PtCl2(C15H20N2S)], was synthesized from the reaction between N-heterocyclic carbene(NHC)-thio­ether ligand and potassium tetra­chloro­platinate. In the crystal, the mol­ecules are linked via C—H⋯Cl and C—H⋯π inter­actions, forming a layer parallel to the ab plane.

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The BaII atom in the polymeric title compound, [Ba(C2H6OS)(C6H2N3O7)2], lies on a mirror plane and is coordinated by ten oxygen atoms, two of which stem from symmetry-related DMSO ligands and eight from four symmetry-related picrate anions.

organic compounds


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At 1.782 (2) Å, the Si—N bond is substanti­ally longer than is found in comparable (3,5-di­methyl­pyrazol­yl)silanes. The tri­methyl­silyl group adopts a staggered conformation with respect to the planar 3,5-di­methyl­pyrazolyl unit. C—H⋯N hydrogen bonds between neighboring mol­ecules form a strand of mol­ecules along the b-axis direction.

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The cations in the title salt show π-stacking. The chloride anions, together with the water mol­ecules, form hydrogen-bonded zigzag chains.

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The crystal structure of the title salt is held by N—H⋯Br charge-assisted hydrogen bonds and dipole–dipole inter­actions. In comparison with reference structures, elongation of C—S bonds is observed.

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The mol­ecules of the title compound are linked into sheets by two π–π stacking inter­actions.

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The crystal structure of a sulfone-containing meta­cyclo­phane is discussed.

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The first single-crystal structure of the hydro­chloride salt of a psilocin analogue, specifically 4-hy­droxy-N,N-di-n-propyl­tryptamine (4-HO-DPT) is reported.
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