5-Bromo-2-(phenyl­amino)­benzoic acid

Kang, L.; Long, S.

doi:10.1107/S2414314624001986

organic compounds

IUCrDATA

ISSN: 2414-3146

Volume 9| Part 3| March 2024| x240198

https://doi.org/10.1107/S2414314624001986

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5-Bromo-2-(phenylamino)benzoic acid

Liping Kang ^a and Sihui Long ^a ^*

^aSchool of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, Hubei 430205, People's Republic of China
^*Correspondence e-mail: sihuilong@wit.edu.cn

Edited by W. T. A. Harrison, University of Aberdeen, United Kingdom (Received 23 October 2023; accepted 29 February 2024; online 6 March 2024)

The title compound, C₁₃H₁₀BrNO₂, was obtained by the reaction of 2,5-dibromobenzoic acid and aniline. The molecule is twisted with a dihedral angle between the aromatic rings of 45.74 (11)° and an intramolecular N—H⋯O hydrogen bond is seen. In the crystal, pairwise O—H⋯O hydrogen bonds generate carboxylic acid inversion dimers.

Keywords: synthon; hydrogen bond; acid-acid dimer; crystal structure.

CCDC reference: 2336150

Structure description

Non-steroidal anti-inflammatory drugs are among the most widely used drugs in the world (Enthoven et al., 2017 ). These have anti-inflammatory, antipyretic and analgesic effects and can be sold as prescription drugs and over-the-counter drugs for the treatment of fever, acute or chronic pain and a variety of inflammatory diseases such as osteoarthritis, rheumatoid arthritis, etc (Machado et al., 2021 ).

As part of our studies in this area, we now describe the synthesis by the Ullman reaction (Wolf et al., 2006 ) and the crystal structure of the title compound, C₁₃H₁₀BrNO₂. As a result of steric repulsion, the C1–C6 and C8–C13 aromatic rings are twisted, subtending a dihedral angle of 45.39 (11)°. An intramolecular N7—H7⋯O15 hydrogen bond is seen (Fig. 1, Table 1). In the extended structure, the molecules pair up to form carboxylic acid inversion dimers linked by pairs of O16—H16⋯O15 hydrogen bonds (Fig. 2, Table 1).

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N7—H7⋯O15	0.88	2.00	2.682 (4)	134
O16—H16⋯O15ⁱ	0.84	1.79	2.629 (4)	174
Symmetry code: (i) .

Figure 1
The molecular structure of the title compound with displacement ellipsoids drawn at the 50% probability level.

Figure 2
Packing of the molecules in the title compound (for clarity, H atoms not involved in intermolecular hydrogen bonding are omitted).

Synthesis and crystallization

The title compound was prepared by reacting 2,5-dibromobenzoic acid and aniline in the presence of a catalyst at 403 K (Fig. 3). The product was purified by column chromatography. Single crystals were obtained by slowly evaporating an acetone solution of the title compound.

Figure 3
Synthesis of the title compound.

Refinement

Crystal data, data collection and structure refinement details are summarized in Table 2.

Table 2
Experimental details

Crystal data
Chemical formula	C₁₃H₁₀BrNO₂
M_r	292.13
Crystal system, space group	Monoclinic, P2₁/n
Temperature (K)	90
a, b, c (Å)	15.2054 (3), 3.8818 (1), 19.8109 (4)
β (°)	107.0391 (10)
V (Å³)	1118.00 (4)
Z	4
Radiation type	Mo Kα
μ (mm⁻¹)	3.66
Crystal size (mm)	0.20 × 0.10 × 0.05

Data collection
Diffractometer	Nonius KappaCCD diffractometer
Absorption correction	Multi-scan (SCALEPACK; Otwinowski & Minor, 1997 )
T_min, T_max	0.528, 0.838
No. of measured, independent and observed [I > 2σ(I)] reflections	4587, 2550, 2206
R_int	0.026
(sin θ/λ)_max (Å⁻¹)	0.649

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.038, 0.130, 1.21
No. of reflections	2550
No. of parameters	155
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.67, −0.81
Computer programs: COLLECT (Nonius, 2002 ), DENZO-SMN (Otwinowski & Minor, 1997), SHELXS97 and SHELXL97 (Sheldrick, 2015 ) and XP in SHELXTL (Sheldrick, 2008 ).

Structural data

CCDC reference: 2336150

Crystal structure: contains datablocks global, I. DOI: https://doi.org/10.1107/S2414314624001986/hb4456sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2414314624001986/hb4456Isup2.hkl

Supporting information file. DOI: https://doi.org/10.1107/S2414314624001986/hb4456Isup3.cml

checkCIF report

Computing details top

5-Bromo-2-(phenylamino)benzoic acid top

Crystal data top

C₁₃H₁₀BrNO₂	F(000) = 584
M_r = 292.13	D_x = 1.736 Mg m⁻³
Monoclinic, P2₁/n	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2yn	Cell parameters from 2931 reflections
a = 15.2054 (3) Å	θ = 1.0–27.5°
b = 3.8818 (1) Å	µ = 3.66 mm⁻¹
c = 19.8109 (4) Å	T = 90 K
β = 107.0391 (10)°	Rod, yellow
V = 1118.00 (4) Å³	0.20 × 0.10 × 0.05 mm
Z = 4

Data collection top

Nonius KappaCCD diffractometer	2550 independent reflections
Radiation source: fine-focus sealed tube	2206 reflections with I > 2σ(I)
Graphite monochromator	R_int = 0.026
Detector resolution: 18 pixels mm^-1	θ_max = 27.5°, θ_min = 1.5°
ω scans at fixed χ=55°	h = −19→19
Absorption correction: multi-scan (Scalepack; Otwinowski & Minor, 1997)	k = −4→5
T_min = 0.528, T_max = 0.838	l = −25→25
4587 measured reflections

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F² > 2σ(F²)] = 0.038	Hydrogen site location: inferred from neighbouring sites
wR(F²) = 0.130	H-atom parameters constrained
S = 1.21	w = 1/[σ²(F_o²) + (0.0621P)² + 2.3209P] where P = (F_o² + 2F_c²)/3
2550 reflections	(Δ/σ)_max < 0.001
155 parameters	Δρ_max = 0.67 e Å⁻³
0 restraints	Δρ_min = −0.81 e Å⁻³

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Refinement. Refinement of F² against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F², conventional R-factors R are based on F, with F set to zero for negative F². The threshold expression of F² > 2sigma(F²) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F² are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

The positions of the H atoms attached to N1 and O1 were obtained from a difference Fourier map. The other H atoms were positioned geometrically with C—H = 0.95 Å and constrained to ride on their parent atoms with U_iso(H) = 1.2U_eq(C,N) or 1.5U_eq(O).

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
Br1	0.10141 (2)	0.46781 (11)	0.57989 (2)	0.02709 (16)
C1	0.4236 (2)	0.5204 (8)	0.66869 (17)	0.0142 (7)
C2	0.3806 (2)	0.3697 (9)	0.60154 (16)	0.0129 (6)
C3	0.2839 (2)	0.3583 (9)	0.57554 (16)	0.0142 (6)
H3	0.2554	0.2540	0.5311	0.017*
C4	0.2307 (2)	0.4972 (9)	0.61400 (17)	0.0149 (7)
C5	0.2722 (2)	0.6592 (9)	0.67881 (17)	0.0154 (7)
H5	0.2351	0.7620	0.7044	0.018*
C6	0.3662 (2)	0.6696 (9)	0.70531 (16)	0.0155 (7)
H6	0.3933	0.7796	0.7493	0.019*
N7	0.5173 (2)	0.5306 (8)	0.69514 (15)	0.0172 (6)
H7	0.5482	0.4840	0.6650	0.021*
C8	0.5710 (2)	0.6066 (9)	0.76502 (17)	0.0149 (7)
C9	0.5449 (2)	0.4996 (9)	0.82367 (18)	0.0162 (7)
H9	0.4883	0.3826	0.8176	0.019*
C10	0.6029 (3)	0.5664 (9)	0.89132 (18)	0.0192 (7)
H10	0.5851	0.4970	0.9314	0.023*
C11	0.6858 (3)	0.7323 (10)	0.90048 (18)	0.0221 (8)
H11	0.7246	0.7782	0.9467	0.026*
C12	0.7125 (2)	0.8319 (10)	0.84229 (19)	0.0214 (7)
H12	0.7704	0.9403	0.8487	0.026*
C13	0.6547 (2)	0.7736 (10)	0.77441 (18)	0.0195 (7)
H13	0.6723	0.8478	0.7346	0.023*
C14	0.4345 (2)	0.2211 (9)	0.55789 (16)	0.0156 (7)
O15	0.51870 (16)	0.2210 (7)	0.57446 (12)	0.0211 (6)
O16	0.38326 (17)	0.0837 (7)	0.49767 (12)	0.0199 (5)
H16	0.4176	−0.0037	0.4759	0.030*

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
Br1	0.0193 (2)	0.0366 (3)	0.0254 (2)	0.00184 (16)	0.00662 (16)	−0.00424 (16)
C1	0.0205 (16)	0.0130 (16)	0.0102 (14)	−0.0001 (13)	0.0061 (12)	0.0015 (12)
C2	0.0175 (15)	0.0140 (15)	0.0089 (13)	−0.0007 (13)	0.0063 (12)	0.0002 (12)
C3	0.0191 (16)	0.0128 (15)	0.0104 (14)	0.0001 (13)	0.0036 (12)	0.0012 (12)
C4	0.0149 (15)	0.0170 (17)	0.0130 (15)	0.0015 (13)	0.0043 (12)	0.0030 (12)
C5	0.0232 (17)	0.0128 (16)	0.0132 (14)	0.0021 (14)	0.0100 (13)	0.0008 (13)
C6	0.0222 (17)	0.0144 (16)	0.0097 (13)	0.0028 (14)	0.0041 (12)	−0.0003 (12)
N7	0.0181 (14)	0.0250 (17)	0.0095 (12)	−0.0002 (12)	0.0054 (11)	−0.0044 (11)
C8	0.0179 (16)	0.0148 (16)	0.0114 (14)	0.0014 (13)	0.0034 (12)	−0.0037 (13)
C9	0.0180 (16)	0.0171 (17)	0.0130 (15)	−0.0004 (13)	0.0039 (12)	−0.0013 (13)
C10	0.0238 (18)	0.0208 (18)	0.0122 (15)	0.0067 (14)	0.0040 (13)	−0.0006 (13)
C11	0.0246 (18)	0.0205 (19)	0.0153 (15)	0.0074 (15)	−0.0033 (13)	−0.0035 (14)
C12	0.0169 (16)	0.0216 (19)	0.0235 (17)	0.0012 (15)	0.0023 (14)	−0.0037 (15)
C13	0.0209 (17)	0.0201 (18)	0.0180 (16)	0.0027 (14)	0.0066 (13)	−0.0011 (14)
C14	0.0219 (17)	0.0159 (16)	0.0094 (13)	−0.0006 (14)	0.0053 (12)	−0.0002 (12)
O15	0.0161 (12)	0.0342 (15)	0.0135 (11)	−0.0013 (11)	0.0052 (9)	−0.0074 (11)
O16	0.0169 (12)	0.0315 (15)	0.0123 (11)	−0.0035 (11)	0.0058 (9)	−0.0096 (10)

Geometric parameters (Å, º) top

Br1—C4	1.885 (3)	C8—C13	1.390 (5)
C1—N7	1.368 (5)	C8—C9	1.397 (5)
C1—C6	1.412 (5)	C9—C10	1.396 (5)
C1—C2	1.424 (4)	C9—H9	0.9500
C2—C3	1.409 (5)	C10—C11	1.379 (6)
C2—C14	1.471 (4)	C10—H10	0.9500
C3—C4	1.374 (5)	C11—C12	1.385 (5)
C3—H3	0.9500	C11—H11	0.9500
C4—C5	1.403 (5)	C12—C13	1.393 (5)
C5—C6	1.371 (5)	C12—H12	0.9500
C5—H5	0.9500	C13—H13	0.9500
C6—H6	0.9500	C14—O15	1.226 (4)
N7—C8	1.417 (4)	C14—O16	1.330 (4)
N7—H7	0.8800	O16—H16	0.8400

N7—C1—C6	121.5 (3)	C13—C8—N7	118.1 (3)
N7—C1—C2	120.7 (3)	C9—C8—N7	121.9 (3)
C6—C1—C2	117.7 (3)	C10—C9—C8	119.3 (3)
C3—C2—C1	119.8 (3)	C10—C9—H9	120.3
C3—C2—C14	118.3 (3)	C8—C9—H9	120.3
C1—C2—C14	121.9 (3)	C11—C10—C9	120.6 (3)
C4—C3—C2	120.4 (3)	C11—C10—H10	119.7
C4—C3—H3	119.8	C9—C10—H10	119.7
C2—C3—H3	119.8	C10—C11—C12	120.0 (3)
C3—C4—C5	120.2 (3)	C10—C11—H11	120.0
C3—C4—Br1	120.0 (3)	C12—C11—H11	120.0
C5—C4—Br1	119.9 (3)	C11—C12—C13	120.1 (4)
C6—C5—C4	120.2 (3)	C11—C12—H12	119.9
C6—C5—H5	119.9	C13—C12—H12	119.9
C4—C5—H5	119.9	C8—C13—C12	119.9 (3)
C5—C6—C1	121.5 (3)	C8—C13—H13	120.0
C5—C6—H6	119.2	C12—C13—H13	120.0
C1—C6—H6	119.2	O15—C14—O16	122.1 (3)
C1—N7—C8	128.2 (3)	O15—C14—C2	124.1 (3)
C1—N7—H7	115.9	O16—C14—C2	113.8 (3)
C8—N7—H7	115.9	C14—O16—H16	109.5
C13—C8—C9	119.9 (3)

N7—C1—C2—C3	179.3 (3)	C1—N7—C8—C13	−147.3 (4)
C6—C1—C2—C3	−3.1 (5)	C1—N7—C8—C9	36.8 (5)
N7—C1—C2—C14	−0.3 (5)	C13—C8—C9—C10	0.9 (5)
C6—C1—C2—C14	177.3 (3)	N7—C8—C9—C10	176.7 (3)
C1—C2—C3—C4	1.1 (5)	C8—C9—C10—C11	−0.9 (5)
C14—C2—C3—C4	−179.3 (3)	C9—C10—C11—C12	−0.5 (6)
C2—C3—C4—C5	1.6 (5)	C10—C11—C12—C13	1.8 (6)
C2—C3—C4—Br1	−178.1 (3)	C9—C8—C13—C12	0.4 (5)
C3—C4—C5—C6	−2.2 (5)	N7—C8—C13—C12	−175.6 (3)
Br1—C4—C5—C6	177.4 (3)	C11—C12—C13—C8	−1.7 (6)
C4—C5—C6—C1	0.2 (5)	C3—C2—C14—O15	178.8 (3)
N7—C1—C6—C5	−180.0 (3)	C1—C2—C14—O15	−1.6 (6)
C2—C1—C6—C5	2.4 (5)	C3—C2—C14—O16	−1.2 (5)
C6—C1—N7—C8	15.9 (5)	C1—C2—C14—O16	178.4 (3)
C2—C1—N7—C8	−166.6 (3)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
N7—H7···O15	0.88	2.00	2.682 (4)	134
O16—H16···O15ⁱ	0.84	1.79	2.629 (4)	174

Symmetry code: (i) −x+1, −y, −z+1.

Funding information

LK and SL thank the Graduate Innovation Fund of WIT for financial support (CX2022055).

References

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