organic compounds
3-(1-{[1-(4-Bromophenyl)-1H-1,2,3-triazol-4-yl]methyl}piperidin-4-yl)-6-fluoro-1,2-benzoxazole hemihydrate
aDepartment of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India, bInstitution of Excellence, University of Mysore, Manasagangotri, Mysore 570 006, India, and cDepartment of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570 006, India
*Correspondence e-mail: rangappaks@chemistry.uni-mysore.ac.in
The title compound, C21H19BrFN5O·0.5H2O, crystallizes as a hemihydrate with the water molecule located on a twofold rotation axis. The piperidine ring has a chair conformation, whereas the triazole and the benzisoxazole rings are planar (r.m.s. deviations = 0.006 and 0.009 Å, respectively). The N—C and C—C bonds connecting the triazole and benzisoxazole rings, respectively, to the piperidine ring lie in equatorial positions. In the crystal, molecules related by a twofold rotation axis are linked via O—H⋯N hydrogen bonds involving the water molecule and a pair of C—H⋯N hydrogen bonds forming dimers. The dimers are linked via a pair of C—H⋯F hydrogen bonds leading to the formation of chains propagating along [101].
Keywords: crystal structure; triazole; piperidine; isoxazole; hydrogen bonding..
CCDC reference: 1443736
Structure description
Benzisoxazoles display a wide spectrum of biological activities namely antipsychotic, antitumor (Jain & Kwon, 2003), anticonvulsant, antimicrobial (Priya et al., 2005), antithrombotic and cholinesterase inhibiting (Alzheimer's disease) properties (Rangappa & Basappa, 2005). In addition the benzisoxazole nucleus is found in a large number of pharmaceutical products, and is used in prodrugs. 1,2,4-Triazole and its derivatives belong to a class of exceptionally active compounds possessing a wide spectrum of biological properties, including anti-inflammatory, antifungal, antiviral, analgesic, anticonvulsant, antiparasitic and antidepressant activities (Naveen et al., 2006). Some triazole derivatives are also known to exhibit anticancer activity. 1,2,4-Triazoles have also been investigated for their CNS depressant, pesticidal, antimycobacterial, hypoglycemic, diuretic, insecticidal and herbicidal effects (Benaka Prasad et al., 2007). In view of the above and as a part of our ongoing research on novel the title compound was synthesized by click reaction with good yield.
The title compound, Fig. 1, crystallizes as a hemihdyrate with the water molecule located on a twofold rotation axis. The piperidine ring has a chair conformation whereas the triazole and the benzisoxazole rings are planar (r.m.s. deviations are 0.006 and 0.009 Å, respectively). The bonds N4—C17 and C11—C9 connecting the triazole and the benzisoxazole rings, respectively, lie in equatorial positions on the piperidine ring.
In the crystal, molecules related by a twofold rotation axis are linked via O—H⋯N hydrogen bonds, involving the water molecule, and a pair of C—H⋯N hydrogen bonds forming dimers. The dimers are linked via a pair of C—H⋯F hydrogen bonds leading to the formation of chains propagating along [101]; see Table 1 and Fig. 2.
Synthesis and crystallization
To the stirred solution of 1-azido bromobenzene (2 mmol) and alkyne (2 mmol) in 2 ml of acetonitrile and 1 ml of water, copper iodide (0.2 mmol) was added at ambient temperature. The reaction mixture was stirred at room temperature for 4–8 h (monitored by TLC). On completion of the reaction, the mixture was poured into ice cold water (10 ml), extracted with ethyl acetate (3 × 10 ml). The combined organic layer was washed with water (10 ml), followed by brine (10 ml) and dried over anhydrous sodium sulfate, concentrated under reduced pressure to get the crude triazole, which was purified by 1H NMR(400 MHz, DMSO-d6, p.p.m.): δ = 7.94 (s, 1H),7.72–7.69 (m, 1H, Ar—H), 7.66–7.61 (m, 4H, Ar—H), 7.24–7.00 (m, 1H, Ar—H), 3.81 (s, 2H), 3.14–3.09 (m, 4H), 2.33–2.31 (m,1H), 2.22–2.09 (m, 4H). 13C NMR (400 MHz, DMSO-d6, p.p.m.): δ = 160.4, 156.5, 148.2, 136.2, 133.2, 129.2, 128.0, 123.7, 123.1, 119.2, 117.5, 111.3, 57.6, 54.1, 30.1, 27.5. LCMS (MM: ES + APCL) 456.10, 458.10 (M + H)+. HPLC purity = 95%. Anal. calc. for C21H19N5O3FBr: C, 55.27; H, 4.20; N, 15.35%; found: C, 56.15; H, 4.03; N, 15.88%.
over silica gel (60–120 mesh) using hexane:EtOAc (8:2) as Good quality single crystals were obtained in good yield by slow evaporation of the solvent.Refinement
Crystal data, data collection and structure .
details are summarized in Table 2Structural data
CCDC reference: 1443736
10.1107/S241431461502458X/su4004sup1.cif
contains datablocks global, I. DOI:Structure factors: contains datablock I. DOI: 10.1107/S241431461502458X/su4004Isup2.hkl
Supporting information file. DOI: 10.1107/S241431461502458X/su4004Isup3.cml
To the stirred solution of 1-azido bromobenzene (2 mmol) and alkyne (2 mmol) in 2 ml of acetonitrile and 1 ml of water, copper iodide (0.2 mmol) was added at ambient temperature. The reaction mixture was stirred at room temperature for 4–8 h (monitored by TLC). On completion of the reaction, the mixture was poured into ice cold water (10 ml), extracted with ethyl acetate (3 × 10 ml). The combined organic layer was washed with water (10 ml), followed by brine (10 ml) and dried over anhydrous sodium sulfate, concentrated under reduced pressure to get crude triazole, which was purified by δ = 7.94 (s, 1H),7.72–7.69 (m, 1H, Ar—H), 7.66–7.61 (m, 4H, Ar—H), 7.24–7.00 (m, 1H, Ar—H), 3.81 (s, 2H), 3.14–3.09 (m, 4H), 2.33–2.31 (m,1H), 2.22–2.09 (m, 4H). 13C NMR (400 MHz, DMSO-d6, p.p.m.): δ = 160.4, 156.5, 148.2, 136.2, 133.2, 129.2, 128.0, 123.7, 123.1, 119.2, 117.5, 111.3, 57.6, 54.1, 30.1, 27.5. LCMS (MM: ES + APCL) 456.10, 458.10 (M + H)+. HPLC purity = 95%. Anal. calc. for C21H19N5O3FBr: C, 55.27; H, 4.20; N, 15.35%; found: C, 56.15; H, 4.03; N, 15.88%.
over silica gel (60–120 mesh) using hexane:EtOAc (8:2) as Good quality single crystals were obtained by slow evaporation of the solvent in good yield. 1H NMR(400 MHz, DMSO-d~6~, p.p.m.):Benzisoxazoles display a wide spectrum of biological activities namely antipsychotic, antitumor (Jain & Kwon, 2003), anticonvulsant, antimicrobial (Priya et al., 2005), antithrombotic and cholinesterase inhibiting (Alzheimer's disease) properties (Rangappa & Basappa, 2005). In addition the benzisoxazole nucleus is found in a large number of pharmaceutical products, and is used as pro drugs. 1,2,4-Triazole and its derivatives belong to a class of exceptionally active compounds possessing a wide spectrum of biological properties, including anti-inflammatory, antifungal, antiviral, analgesic, anticonvulsant, antiparasitic and antidepressant activities (Naveen et al., 2006). Some triazole derivatives are also known to exhibit anticancer activity. 1,2,4-Triazoles have also been investigated for their CNS depressant, pesticidal, antimycobacterial, hypoglycemic, diuretic, insecticidal and herbicidal effects (Benaka Prasad et al., 2007). In view of the above and as a part of our ongoing research on novel
the title compound was synthesized by click reaction with good yield.The title compound, Fig. 1, crystallizes as a hemihdyrate with the water molecule located on a twofold rotation axis. The piperidine ring has a chair conformation whereas the triazole and the benzisoxazole rings are planar (r.m.s. deviations are 0.006 and 0.009 Å, respectively). The bonds N4—C17 and C11—C9 connecting the triazole and the benzisoxazole rings, respectively, lie in equatorial positions on the piperidine ring.
In the crystal, molecules related by a twofold rotation axis are linked via O—H···N hydrogen bonds, involving the water molecule, and a pair of C—H···N hydrogen bonds forming dimers. The dimers are linked via a pair of C—H···F hydrogen bonds leading to the formation of chains propagating along [101]; see Table 1 and Figs. 2 and 3.
Data collection: APEX2 (Bruker, 2013); cell
SAINT (Bruker, 2013); data reduction: SAINT (Bruker, 2013)'; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: Mercury (Macrae et al., 2008); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008) and PLATON (Spek, 2009).Fig. 1. A view of the molecular structure of the title compound, with the atom labelling. Displacement ellipsoids are drawn at the 50% probability level. | |
Fig. 2. A view in projection along the b axis of the crystal packing of the title compound. Hydrogen bonds are shown as dashed lines (see Table 1), and H atoms not involved in hydrogen bonding have been omitted for clarity. |
C21H19BrFN5O·0.5H2O | F(000) = 1896 |
Mr = 465.33 | Dx = 1.559 Mg m−3 |
Monoclinic, C2/c | Cu Kα radiation, λ = 1.54178 Å |
Hall symbol: -C 2yc | Cell parameters from 3195 reflections |
a = 34.4311 (10) Å | θ = 5.0–64.3° |
b = 5.6779 (2) Å | µ = 3.13 mm−1 |
c = 20.2869 (6) Å | T = 296 K |
β = 91.107 (1)° | Rectangle, yellow |
V = 3965.3 (2) Å3 | 0.30 × 0.27 × 0.25 mm |
Z = 8 |
Bruker X8 Proteum diffractometer | 3195 independent reflections |
Radiation source: Rotating Anode | 3080 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.034 |
Detector resolution: 18.4 pixels mm-1 | θmax = 64.3°, θmin = 5.0° |
φ and ω scans | h = −40→38 |
Absorption correction: multi-scan (SADABS; Bruker, 2013) | k = −6→6 |
Tmin = 0.454, Tmax = 0.508 | l = −22→23 |
11135 measured reflections |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.033 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.096 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.10 | w = 1/[σ2(Fo2) + (0.0573P)2 + 5.9658P] where P = (Fo2 + 2Fc2)/3 |
3195 reflections | (Δ/σ)max = 0.002 |
271 parameters | Δρmax = 0.48 e Å−3 |
1 restraint | Δρmin = −0.45 e Å−3 |
C21H19BrFN5O·0.5H2O | V = 3965.3 (2) Å3 |
Mr = 465.33 | Z = 8 |
Monoclinic, C2/c | Cu Kα radiation |
a = 34.4311 (10) Å | µ = 3.13 mm−1 |
b = 5.6779 (2) Å | T = 296 K |
c = 20.2869 (6) Å | 0.30 × 0.27 × 0.25 mm |
β = 91.107 (1)° |
Bruker X8 Proteum diffractometer | 3195 independent reflections |
Absorption correction: multi-scan (SADABS; Bruker, 2013) | 3080 reflections with I > 2σ(I) |
Tmin = 0.454, Tmax = 0.508 | Rint = 0.034 |
11135 measured reflections |
R[F2 > 2σ(F2)] = 0.033 | 1 restraint |
wR(F2) = 0.096 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.10 | Δρmax = 0.48 e Å−3 |
3195 reflections | Δρmin = −0.45 e Å−3 |
271 parameters |
Geometry. Bond distances, angles etc. have been calculated using the rounded fractional coordinates. All su's are estimated from the variances of the (full) variance-covariance matrix. The cell e.s.d.'s are taken into account in the estimation of distances, angles and torsion angles |
Refinement. Refinement on F2 for ALL reflections except those flagged by the user for potential systematic errors. Weighted R-factors wR and all goodnesses of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The observed criterion of F2 > σ(F2) is used only for calculating -R-factor-obs etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
Br29 | 0.72298 (1) | 1.29638 (4) | 0.28345 (1) | 0.0287 (1) | |
F10 | 0.23150 (4) | 0.0267 (3) | 0.44145 (7) | 0.0357 (5) | |
O2 | 0.33559 (5) | 0.4753 (3) | 0.35433 (8) | 0.0283 (5) | |
N1 | 0.37653 (6) | 0.4371 (4) | 0.35741 (11) | 0.0285 (6) | |
N14 | 0.50507 (5) | 0.1278 (3) | 0.36583 (10) | 0.0217 (6) | |
N19 | 0.58992 (6) | 0.2882 (4) | 0.44413 (11) | 0.0288 (7) | |
N20 | 0.61405 (6) | 0.4651 (4) | 0.43820 (10) | 0.0284 (6) | |
N21 | 0.61341 (5) | 0.5296 (3) | 0.37376 (9) | 0.0215 (6) | |
C3 | 0.31868 (7) | 0.2941 (4) | 0.38620 (12) | 0.0236 (7) | |
C4 | 0.27888 (7) | 0.2670 (5) | 0.39576 (12) | 0.0267 (8) | |
C5 | 0.26950 (7) | 0.0657 (5) | 0.42895 (12) | 0.0265 (7) | |
C6 | 0.29596 (7) | −0.1025 (4) | 0.45121 (11) | 0.0270 (7) | |
C7 | 0.33528 (7) | −0.0691 (4) | 0.44156 (11) | 0.0237 (7) | |
C8 | 0.34652 (7) | 0.1361 (4) | 0.40874 (11) | 0.0218 (7) | |
C9 | 0.38264 (7) | 0.2405 (4) | 0.38924 (12) | 0.0232 (7) | |
C11 | 0.42293 (7) | 0.1504 (4) | 0.40130 (12) | 0.0233 (7) | |
C12 | 0.45141 (7) | 0.3549 (4) | 0.41267 (12) | 0.0238 (7) | |
C13 | 0.49289 (7) | 0.2656 (4) | 0.42274 (12) | 0.0224 (7) | |
C15 | 0.47923 (7) | −0.0769 (4) | 0.35656 (13) | 0.0280 (7) | |
C16 | 0.43714 (7) | −0.0008 (4) | 0.34432 (12) | 0.0268 (7) | |
C17 | 0.54513 (7) | 0.0420 (4) | 0.37479 (13) | 0.0274 (7) | |
C18 | 0.57400 (7) | 0.2368 (4) | 0.38362 (13) | 0.0242 (7) | |
C22 | 0.58880 (7) | 0.3897 (4) | 0.33872 (12) | 0.0243 (7) | |
C23 | 0.63796 (7) | 0.7157 (4) | 0.35159 (12) | 0.0212 (7) | |
C24 | 0.65390 (7) | 0.8705 (5) | 0.39741 (12) | 0.0273 (7) | |
C25 | 0.67846 (7) | 1.0469 (5) | 0.37636 (12) | 0.0279 (7) | |
C26 | 0.68691 (7) | 1.0639 (4) | 0.31016 (12) | 0.0237 (7) | |
C27 | 0.67048 (8) | 0.9124 (4) | 0.26426 (12) | 0.0296 (8) | |
C28 | 0.64577 (8) | 0.7368 (5) | 0.28518 (13) | 0.0283 (8) | |
O30 | 0.50000 | 0.4399 (5) | 0.25000 | 0.0372 (9) | |
H4 | 0.26050 | 0.37560 | 0.38100 | 0.0320* | |
H6 | 0.28730 | −0.23710 | 0.47250 | 0.0320* | |
H7 | 0.35350 | −0.17880 | 0.45630 | 0.0280* | |
H11 | 0.42290 | 0.05300 | 0.44120 | 0.0280* | |
H12A | 0.45030 | 0.45990 | 0.37500 | 0.0290* | |
H12B | 0.44380 | 0.44360 | 0.45120 | 0.0290* | |
H13A | 0.51030 | 0.39840 | 0.42900 | 0.0270* | |
H13B | 0.49440 | 0.16860 | 0.46210 | 0.0270* | |
H15A | 0.48070 | −0.17590 | 0.39550 | 0.0340* | |
H15B | 0.48790 | −0.16910 | 0.31940 | 0.0340* | |
H16A | 0.43520 | 0.08830 | 0.30360 | 0.0320* | |
H16B | 0.42080 | −0.13910 | 0.33970 | 0.0320* | |
H17A | 0.55200 | −0.05100 | 0.33670 | 0.0330* | |
H17B | 0.54640 | −0.06010 | 0.41310 | 0.0330* | |
H22 | 0.58320 | 0.39640 | 0.29370 | 0.0290* | |
H24 | 0.64820 | 0.85600 | 0.44180 | 0.0330* | |
H25 | 0.68920 | 1.15310 | 0.40650 | 0.0330* | |
H27 | 0.67600 | 0.92830 | 0.21980 | 0.0360* | |
H28 | 0.63450 | 0.63350 | 0.25480 | 0.0340* | |
H30 | 0.4993 (11) | 0.342 (5) | 0.2205 (13) | 0.054 (11)* |
U11 | U22 | U33 | U12 | U13 | U23 | |
Br29 | 0.0303 (2) | 0.0306 (2) | 0.0252 (2) | −0.0042 (1) | 0.0009 (1) | 0.0021 (1) |
F10 | 0.0231 (7) | 0.0524 (9) | 0.0319 (8) | −0.0093 (6) | 0.0054 (6) | 0.0010 (7) |
O2 | 0.0230 (8) | 0.0290 (9) | 0.0326 (10) | −0.0011 (7) | −0.0032 (7) | 0.0101 (7) |
N1 | 0.0214 (10) | 0.0314 (11) | 0.0325 (12) | −0.0036 (8) | −0.0026 (9) | 0.0106 (9) |
N14 | 0.0218 (10) | 0.0183 (9) | 0.0249 (10) | −0.0014 (8) | −0.0012 (8) | 0.0003 (8) |
N19 | 0.0243 (11) | 0.0371 (13) | 0.0248 (12) | −0.0036 (9) | −0.0006 (9) | 0.0003 (9) |
N20 | 0.0283 (11) | 0.0366 (11) | 0.0203 (10) | −0.0035 (9) | 0.0013 (8) | −0.0005 (9) |
N21 | 0.0165 (9) | 0.0287 (10) | 0.0191 (10) | −0.0001 (8) | −0.0024 (7) | −0.0030 (8) |
C3 | 0.0287 (13) | 0.0241 (12) | 0.0179 (12) | −0.0040 (9) | −0.0002 (10) | 0.0012 (8) |
C4 | 0.0236 (13) | 0.0345 (13) | 0.0220 (13) | 0.0003 (10) | −0.0009 (10) | −0.0009 (10) |
C5 | 0.0203 (12) | 0.0399 (13) | 0.0193 (12) | −0.0073 (10) | 0.0011 (9) | −0.0039 (10) |
C6 | 0.0321 (13) | 0.0312 (13) | 0.0177 (12) | −0.0113 (10) | 0.0014 (10) | 0.0009 (10) |
C7 | 0.0286 (12) | 0.0258 (11) | 0.0165 (11) | −0.0046 (10) | −0.0027 (9) | 0.0007 (9) |
C8 | 0.0258 (12) | 0.0243 (11) | 0.0151 (11) | −0.0044 (10) | −0.0026 (9) | −0.0013 (9) |
C9 | 0.0246 (13) | 0.0247 (11) | 0.0202 (12) | −0.0055 (10) | −0.0019 (10) | 0.0015 (9) |
C11 | 0.0210 (11) | 0.0258 (11) | 0.0230 (12) | −0.0048 (10) | −0.0033 (9) | 0.0072 (10) |
C12 | 0.0234 (12) | 0.0245 (11) | 0.0235 (12) | −0.0029 (10) | −0.0006 (9) | −0.0032 (9) |
C13 | 0.0227 (12) | 0.0239 (11) | 0.0205 (12) | −0.0037 (9) | −0.0028 (9) | 0.0011 (9) |
C15 | 0.0275 (12) | 0.0194 (11) | 0.0370 (14) | −0.0031 (9) | −0.0046 (10) | −0.0015 (10) |
C16 | 0.0252 (12) | 0.0215 (11) | 0.0335 (14) | −0.0046 (9) | −0.0075 (10) | 0.0005 (10) |
C17 | 0.0264 (12) | 0.0226 (11) | 0.0330 (14) | 0.0001 (10) | −0.0015 (10) | 0.0001 (10) |
C18 | 0.0190 (12) | 0.0276 (11) | 0.0258 (13) | 0.0035 (9) | −0.0032 (10) | −0.0025 (10) |
C22 | 0.0218 (12) | 0.0290 (12) | 0.0219 (12) | 0.0014 (10) | −0.0065 (9) | −0.0027 (10) |
C23 | 0.0172 (11) | 0.0252 (12) | 0.0212 (12) | 0.0031 (9) | −0.0019 (9) | −0.0024 (9) |
C24 | 0.0260 (12) | 0.0371 (13) | 0.0188 (12) | −0.0057 (11) | 0.0002 (9) | −0.0041 (10) |
C25 | 0.0277 (12) | 0.0339 (13) | 0.0220 (12) | −0.0041 (10) | −0.0005 (10) | −0.0075 (10) |
C26 | 0.0225 (11) | 0.0256 (11) | 0.0228 (12) | 0.0035 (9) | −0.0009 (9) | 0.0007 (9) |
C27 | 0.0383 (14) | 0.0323 (13) | 0.0183 (12) | −0.0019 (11) | 0.0029 (10) | −0.0002 (10) |
C28 | 0.0330 (14) | 0.0311 (12) | 0.0208 (13) | −0.0033 (11) | −0.0021 (11) | −0.0069 (10) |
O30 | 0.0627 (18) | 0.0260 (13) | 0.0229 (14) | 0.0000 | 0.0005 (13) | 0.0000 |
Br29—C26 | 1.899 (2) | C17—C18 | 1.496 (3) |
F10—C5 | 1.356 (3) | C18—C22 | 1.364 (3) |
O2—N1 | 1.426 (3) | C23—C24 | 1.385 (4) |
O2—C3 | 1.353 (3) | C23—C28 | 1.384 (4) |
O30—H30i | 0.82 (3) | C24—C25 | 1.384 (4) |
O30—H30 | 0.82 (3) | C25—C26 | 1.383 (3) |
N1—C9 | 1.305 (3) | C26—C27 | 1.381 (3) |
N14—C13 | 1.463 (3) | C27—C28 | 1.383 (4) |
N14—C17 | 1.471 (3) | C4—H4 | 0.9300 |
N14—C15 | 1.474 (3) | C6—H6 | 0.9300 |
N19—C18 | 1.366 (3) | C7—H7 | 0.9300 |
N19—N20 | 1.311 (3) | C11—H11 | 0.9800 |
N20—N21 | 1.357 (3) | C12—H12B | 0.9700 |
N21—C22 | 1.353 (3) | C12—H12A | 0.9700 |
N21—C23 | 1.431 (3) | C13—H13B | 0.9700 |
C3—C4 | 1.396 (3) | C13—H13A | 0.9700 |
C3—C8 | 1.384 (3) | C15—H15A | 0.9700 |
C4—C5 | 1.368 (4) | C15—H15B | 0.9700 |
C5—C6 | 1.389 (4) | C16—H16B | 0.9700 |
C6—C7 | 1.385 (3) | C16—H16A | 0.9700 |
C7—C8 | 1.400 (3) | C17—H17B | 0.9700 |
C8—C9 | 1.440 (3) | C17—H17A | 0.9700 |
C9—C11 | 1.494 (3) | C22—H22 | 0.9300 |
C11—C16 | 1.528 (3) | C24—H24 | 0.9300 |
C11—C12 | 1.534 (3) | C25—H25 | 0.9300 |
C12—C13 | 1.526 (3) | C27—H27 | 0.9300 |
C15—C16 | 1.528 (3) | C28—H28 | 0.9300 |
N1—O2—C3 | 107.31 (18) | C26—C27—C28 | 119.3 (2) |
H30—O30—H30i | 94 (3) | C23—C28—C27 | 119.6 (2) |
O2—N1—C9 | 107.55 (19) | C5—C4—H4 | 123.00 |
C13—N14—C15 | 109.94 (18) | C3—C4—H4 | 123.00 |
C15—N14—C17 | 108.48 (17) | C5—C6—H6 | 120.00 |
C13—N14—C17 | 111.23 (19) | C7—C6—H6 | 120.00 |
N20—N19—C18 | 109.0 (2) | C6—C7—H7 | 121.00 |
N19—N20—N21 | 107.26 (19) | C8—C7—H7 | 121.00 |
N20—N21—C23 | 120.21 (18) | C12—C11—H11 | 108.00 |
C22—N21—C23 | 129.5 (2) | C16—C11—H11 | 108.00 |
N20—N21—C22 | 110.24 (18) | C9—C11—H11 | 108.00 |
O2—C3—C8 | 110.4 (2) | C11—C12—H12A | 109.00 |
C4—C3—C8 | 123.9 (2) | C13—C12—H12A | 109.00 |
O2—C3—C4 | 125.7 (2) | C13—C12—H12B | 109.00 |
C3—C4—C5 | 113.7 (2) | C11—C12—H12B | 109.00 |
F10—C5—C6 | 117.1 (2) | H12A—C12—H12B | 108.00 |
C4—C5—C6 | 125.1 (2) | N14—C13—H13B | 110.00 |
F10—C5—C4 | 117.8 (2) | C12—C13—H13A | 109.00 |
C5—C6—C7 | 119.8 (2) | C12—C13—H13B | 110.00 |
C6—C7—C8 | 117.5 (2) | H13A—C13—H13B | 108.00 |
C3—C8—C7 | 120.0 (2) | N14—C13—H13A | 109.00 |
C3—C8—C9 | 103.8 (2) | N14—C15—H15B | 109.00 |
C7—C8—C9 | 136.2 (2) | C16—C15—H15A | 109.00 |
N1—C9—C11 | 121.0 (2) | N14—C15—H15A | 109.00 |
C8—C9—C11 | 128.2 (2) | H15A—C15—H15B | 108.00 |
N1—C9—C8 | 110.9 (2) | C16—C15—H15B | 109.00 |
C9—C11—C16 | 112.2 (2) | C11—C16—H16A | 109.00 |
C12—C11—C16 | 109.02 (19) | C11—C16—H16B | 110.00 |
C9—C11—C12 | 110.74 (19) | C15—C16—H16B | 109.00 |
C11—C12—C13 | 111.26 (19) | H16A—C16—H16B | 108.00 |
N14—C13—C12 | 110.73 (19) | C15—C16—H16A | 110.00 |
N14—C15—C16 | 111.48 (18) | N14—C17—H17B | 109.00 |
C11—C16—C15 | 110.6 (2) | C18—C17—H17A | 109.00 |
N14—C17—C18 | 112.92 (18) | C18—C17—H17B | 109.00 |
N19—C18—C17 | 121.3 (2) | H17A—C17—H17B | 108.00 |
N19—C18—C22 | 108.4 (2) | N14—C17—H17A | 109.00 |
C17—C18—C22 | 130.3 (2) | C18—C22—H22 | 127.00 |
N21—C22—C18 | 105.1 (2) | N21—C22—H22 | 127.00 |
N21—C23—C24 | 119.1 (2) | C23—C24—H24 | 120.00 |
C24—C23—C28 | 121.1 (2) | C25—C24—H24 | 120.00 |
N21—C23—C28 | 119.8 (2) | C26—C25—H25 | 120.00 |
C23—C24—C25 | 119.3 (2) | C24—C25—H25 | 120.00 |
C24—C25—C26 | 119.4 (2) | C26—C27—H27 | 120.00 |
Br29—C26—C27 | 120.16 (18) | C28—C27—H27 | 120.00 |
C25—C26—C27 | 121.4 (2) | C23—C28—H28 | 120.00 |
Br29—C26—C25 | 118.47 (18) | C27—C28—H28 | 120.00 |
N1—O2—C3—C4 | 178.5 (2) | C5—C6—C7—C8 | −0.5 (3) |
N1—O2—C3—C8 | −1.4 (3) | C6—C7—C8—C3 | −1.2 (3) |
C3—O2—N1—C9 | 0.6 (2) | C6—C7—C8—C9 | 179.3 (3) |
O2—N1—C9—C8 | 0.4 (3) | C3—C8—C9—N1 | −1.1 (3) |
O2—N1—C9—C11 | −179.7 (2) | C3—C8—C9—C11 | 178.9 (2) |
C15—N14—C13—C12 | −60.2 (2) | C7—C8—C9—N1 | 178.4 (3) |
C17—N14—C13—C12 | 179.63 (18) | C7—C8—C9—C11 | −1.6 (5) |
C13—N14—C15—C16 | 60.3 (3) | N1—C9—C11—C12 | 34.8 (3) |
C17—N14—C15—C16 | −177.9 (2) | N1—C9—C11—C16 | −87.3 (3) |
C13—N14—C17—C18 | −59.9 (3) | C8—C9—C11—C12 | −145.3 (2) |
C15—N14—C17—C18 | 179.1 (2) | C8—C9—C11—C16 | 92.7 (3) |
C18—N19—N20—N21 | 0.6 (3) | C9—C11—C12—C13 | −178.1 (2) |
N20—N19—C18—C17 | −179.9 (2) | C16—C11—C12—C13 | −54.1 (3) |
N20—N19—C18—C22 | −0.4 (3) | C9—C11—C16—C15 | 176.53 (19) |
N19—N20—N21—C22 | −0.6 (3) | C12—C11—C16—C15 | 53.5 (2) |
N19—N20—N21—C23 | −178.12 (19) | C11—C12—C13—N14 | 58.2 (2) |
N20—N21—C22—C18 | 0.3 (3) | N14—C15—C16—C11 | −57.5 (3) |
C23—N21—C22—C18 | 177.6 (2) | N14—C17—C18—N19 | 104.5 (3) |
N20—N21—C23—C24 | −17.8 (3) | N14—C17—C18—C22 | −74.9 (3) |
N20—N21—C23—C28 | 161.4 (2) | N19—C18—C22—N21 | 0.1 (3) |
C22—N21—C23—C24 | 165.2 (2) | C17—C18—C22—N21 | 179.5 (2) |
C22—N21—C23—C28 | −15.6 (4) | N21—C23—C24—C25 | 178.3 (2) |
O2—C3—C4—C5 | 179.2 (2) | C28—C23—C24—C25 | −0.9 (4) |
C8—C3—C4—C5 | −1.0 (4) | N21—C23—C28—C27 | −178.0 (2) |
O2—C3—C8—C7 | −178.1 (2) | C24—C23—C28—C27 | 1.3 (4) |
O2—C3—C8—C9 | 1.5 (3) | C23—C24—C25—C26 | −0.6 (4) |
C4—C3—C8—C7 | 2.1 (4) | C24—C25—C26—Br29 | −176.49 (19) |
C4—C3—C8—C9 | −178.3 (2) | C24—C25—C26—C27 | 1.8 (4) |
C3—C4—C5—F10 | 178.9 (2) | Br29—C26—C27—C28 | 176.8 (2) |
C3—C4—C5—C6 | −0.8 (4) | C25—C26—C27—C28 | −1.5 (4) |
F10—C5—C6—C7 | −178.2 (2) | C26—C27—C28—C23 | −0.1 (4) |
C4—C5—C6—C7 | 1.6 (4) |
Symmetry code: (i) −x+1, y, −z+1/2. |
D—H···A | D—H | H···A | D···A | D—H···A |
O30—H30···N14i | 0.82 (3) | 2.14 (3) | 2.946 (3) | 172 (3) |
C28—H28···N1i | 0.93 | 2.56 | 3.430 (4) | 157 |
C6—H6···F10ii | 0.93 | 2.49 | 3.394 (3) | 163 |
Symmetry codes: (i) −x+1, y, −z+1/2; (ii) −x+1/2, −y−1/2, −z+1. |
D—H···A | D—H | H···A | D···A | D—H···A |
O30—H30···N14i | 0.82 (3) | 2.14 (3) | 2.946 (3) | 172 (3) |
C28—H28···N1i | 0.93 | 2.56 | 3.430 (4) | 157 |
C6—H6···F10ii | 0.93 | 2.49 | 3.394 (3) | 163 |
Symmetry codes: (i) −x+1, y, −z+1/2; (ii) −x+1/2, −y−1/2, −z+1. |
Experimental details
Crystal data | |
Chemical formula | C21H19BrFN5O·0.5H2O |
Mr | 465.33 |
Crystal system, space group | Monoclinic, C2/c |
Temperature (K) | 296 |
a, b, c (Å) | 34.4311 (10), 5.6779 (2), 20.2869 (6) |
β (°) | 91.107 (1) |
V (Å3) | 3965.3 (2) |
Z | 8 |
Radiation type | Cu Kα |
µ (mm−1) | 3.13 |
Crystal size (mm) | 0.30 × 0.27 × 0.25 |
Data collection | |
Diffractometer | Bruker X8 Proteum |
Absorption correction | Multi-scan (SADABS; Bruker, 2013) |
Tmin, Tmax | 0.454, 0.508 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 11135, 3195, 3080 |
Rint | 0.034 |
(sin θ/λ)max (Å−1) | 0.584 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.033, 0.096, 1.10 |
No. of reflections | 3195 |
No. of parameters | 271 |
No. of restraints | 1 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.48, −0.45 |
Computer programs: APEX2 (Bruker, 2013), SAINT (Bruker, 2013)', SHELXS97 (Sheldrick, 2008), Mercury (Macrae et al., 2008), SHELXL97 (Sheldrick, 2008) and PLATON (Spek, 2009).
Acknowledgements
KSR acknowledges financial support under the project (BRNS project No. 2009/37/40/BRNS/2266 dated 23–11-2009). NA thanks the CSIR–UGC for a senior research fellowship. The authors are grateful to the IOE, Vijnana Bhavana, University of Mysore, Mysore, for providing the single-crystal X-ray diffractometer facility.
References
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