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Figure 1
General mechanism of enolase in forward catalysis. (a) Opening and closing of the active site loops in enolase. The loop opening is thermodynamically more favorable in the PEP-bound than the 2PG-bound enzyme. Reprinted (adapted) with permission from Li & Hammes-Schiffer (2019BB39). Copyright 2019 American Chemical Society. (b) General catalytic mechanism for forward catalysis. (c) Catalytic cycle for the forward reaction.

IUCrJ
Volume 10| Part 6| November 2023| Pages 738-753
ISSN: 2052-2525
https://doi.org/10.1107/S2052252523008485