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Figure 4
A schematic of the orthosteric binding site comparing key residues of AcAChBP and corresponding amino acids in the nAChR α4(+)β2(−) heteromeric site. Loop F is out of the range of the ligands discussed in this work and has been omitted. Arg96 is included (see text). On the α4(+) side boxes for selected amino-acid positions are colored yellow to highlight strict conservation and gray where the sequence changes. On the β2(−) side the boxes are colored green. Three key positions implicated in the ion-channel response to ligand binding and that are discussed in the text are shown in light green.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 78| Part 9| September 2022| Pages 313-323
https://doi.org/10.1107/S2053230X22007762
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