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ISSN: 2414-3146

February 2018 issue

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Cover illustration: Over the past few years, metformin hydro­chloride (1,1-di­methyl­biguanide hydro­chloride) has been the most commonly used drug for the first-line treatment of type 2 diabetes. On the other hand, acetyl­salicylic acid, which is one of the most used general pain-relieving drugs, has been associated with copper in the form of copper acetyl­salicylate to treat rheumatoid arthritis and thromboembolic diseases. The synthesis and crystal structure of a new CuII complex that contains both active pharmaceutical ingredients chelating to the central metal cation, namely neutral metformin and the salicylate dianion, is reported. The hydrous complex (metformin-[kappa]2N,N')(salicylato-[kappa]2O,O')copper(II) trihydrate [systematic name: (1,1-di­methyl­biguanide-[kappa]2N2,N4)(2-oxidobenzoato-[kappa]2O,O')copper(II) trihydrate] was synthesized electrolytically from an ethano­lic solution of metformin hydro­chloride, acetyl­salicylic acid, Pepto-Bismol and a copper sacrificial anode. Diffraction data were collected at 0.56 Å resolution, allowing the accurate determination of H-atom positions in the neutral metformin ligand. See: Gutiérrez Ojeda, Salazar Kuri, Bernès & Pérez-Benítez [IUCrData (2017). 3, x180180].

inorganic compounds


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The title compound is isostructural with compounds in the CsPr(SO4)2 family.

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The crystal structure of ω-Al4Cr is isotypic with its molybdenum and tungsten analogues.

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Al10Ni3Fe0.83 adopts the Co2Al5 structure type with the Fe site underoccupied.

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The redetermination of the crystal structure of thorium(IV) tetra­iodide is reported and compared with the previous determination.

metal-organic compounds


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A CuII complex including active pharmaceutical ingredients as ligands has been synthesized using commercial drugs and a copper sacrificial anode, affording high-quality single crystals.

organic compounds


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Pairs of mol­ecules are linked through the amino–nitrile N—H⋯N hydrogen bonds, forming inversion dimers. These assemble into a three-dimensional network via C—H⋯O and C—H⋯π inter­actions.

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The crystal structure of a urea resulting from the unexpected decomposition of a Boc-protected aniline is reported. The crystal structure is stabilized by C—H⋯O hydrogen bonds and short Br⋯Br halogen bonds.

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In the title compound, the dihedral angle between the pyrazole ring and nitrone-bound ring is 32.57 (6)°.

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The crystal structure contains three independent mol­ecules in the asymmetric unit. In each mol­ecule, the C and N atoms of the central triazine ring are equally disordered on the same site.

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The structure of a spiro­pyrroline incorporating a thia­zole ring is reported. The crystal structure features C—H⋯N, C—H⋯O, C—H⋯S and C—H⋯Br hydrogen bonds that form both ring and chain motifs.

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In this enamine derivative, the pheno­thia­zine unit has a butterfly structure and the central six-membered ring adopts a boat conformation. The fold angle between the benzene rings is 28.52 (7)°. The crystal structure features Csp3—H⋯Cl and Csp2—H⋯S hydrogen bonds and π–π stacking inter­actions between pheno­thia­zine units.

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The crystal of (4-methyl­phen­yl)methanaminium chloride hemihydrate features C—H⋯Br, O—H⋯Br, N—H⋯Br, and N—H⋯O hydrogen bonds, as well as weak C—H⋯π inter­actions.

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The title compound has been characterized by single-crystal X-ray diffraction, revealing disorder of the carbons on the ethenyl group, hydrogen bonds, and halogen bonds.

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The asymmetric unit consists of two independent mol­ecules differing slightly in the orientation of the di­methyl­amino groups, and two water mol­ecules. In the crystal, a combination of O—H⋯N and N—H⋯O hydrogen bonds involving the lattice water, as well as slipped π-stacking inter­actions between pyrazolo­pyrimidine units form layers parallel to the bc plane.

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The asymmetric unit consists of two independent mol­ecules differing in the orientations of the ester groups. In the crystal, mol­ecules are linked into a ribbon structure via C—H⋯O and C—H⋯π inter­actions.

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The fused ring system of the title pyrido­pyrazine derivative is almost planar.

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The structure of the title di­hydro­quinoline derivative is reported. Its crystal structure features C—H⋯N and C—H⋯O hydrogen bonds and π–π stacking inter­actions between the di­hydro­quinoline units.

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The title compound is built up from two fused phenyl rings. The naphthalene ring system is approximately planar.


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The stucture of an aceto­phenone derivative that lies on a mirror plane is reported. The crystal structure is stabilized by N—H⋯O and very weak π–π stacking inter­actions.
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