journal menu
issue contents
October 2023 issue
Cover illustration: An inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1 [Moorefield et al. (2023), Acta Cryst. F79, 257–266]. Inorganic pyrophosphate (PPi) is generated as an intermediate or byproduct of many fundamental metabolic pathways, including DNA/RNA synthesis. The crystal structure of a family I inorganic pyrophosphatase from Legionella pneumophila, a human opportunistic pathogen that is the major causative agent of Legionnaires' disease, has been determined.
research communications
Open 
access
access
Biochemical and X-ray analyses of the players involved in the faRel2/aTfaRel2 toxin–antitoxin operon
Crystallization strategies for and structural analyses of all of the players in the faRel2/aTfaRel2 toxin–antitoxin system are reported.
The crystal structure of a soluble family I inorganic pyrophosphatase from L. pneumophila Philadelphia 1 was determined to a resolution of 2.0 Å. Inorganic pyrophosphatases play a central role in regulating cellular pyrophosphate concentration, which is important for many biosynthetic pathways. L. pneumophila Philadelphia 1 causes a rare but severe respiratory infection known as Legionnaires' disease.
methods communications
Open access
access
Guidance is provided on depositing raw diffraction data to support the results described in a macromolecular crystallography paper.
scientific commentaries
Free
The article by Moorefield et al. [(2023), Acta Cryst. F79, 257–266] demonstrates how structural genomics depositions can be used in undergraduate teaching.
![[publBio]](/logos/publbio.gif)
